Guise was a distinguished ducal family of France, a branch of the house of Lorraine. The founder was Claude Guise, a son of Rene II, duke of Lorraine, who in 1506 became naturalized in France. In his favour the county of Guise was erected in 1528 by Francis I into a duchy. He died in 1550, leaving behind him five daughters (the eldest of whom, Marie, married James V of Scotland, and was the mother of Mary, queen of Scots) and six sons - Francois, who succeeded him, Charles (Cardinal of Lorraine), Louis (Cardinal of Guise), Claude, Francois, and Rene. The family acquired great political importance on the accession of Francis II, who was married to Mary, queen of Scots. The direct line became extinct in 1675. In 1704 the title was revived for the house of Conde. Research Guise
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