The Probert Encyclopaedia of Medicine

ALBUMIN

Albumin is one of the three main components of plasma. The other two proteins are globulins and fibrinogen. All three proteins are manufactured by the liver. These three proteins circulate in plasma and act as carriers for small molecules. Albumin, the most plentiful, is similar in texture to egg whites and gives blood its gummy texture. It is soluble in water and coagulable by heat. The globulins, three in number: alpha, beta, and gamma. They are divided on the basis of electrophoretic mobility. The globulins transport certain proteins. They number half the albumin proteins found in plasma. The globulin proteins are insoluble in water, soluble in saline solutions, and coagulable by heat. Globulins are also found in cerebrospinal fluid. Gamma globulins are the antibodies of the blood, giving immunity to disease. Only 3% of plasma is made up of fibrinogen. It is an important link in the chain of reactions that leads to blood clotting (coagulation). It uses the enzyme thrombin to form a web of fine protein fibres, called fibrin, that bind blood cells together, creating a bridge over which injured tissue can rebuild itself while blood continues to flow underneath. As an important factor to coagulation, it is often referred to as factor I.
Research Albumin