Cholera is an infectious disease caused by the micro organism Vibrio cholerae. It is endemic in India and some other tropical countries and occasionally spreading to temperate climates. The symptoms of cholera are diarrhoea and the loss of water and salts in the stool. In severe cholera, the patient develops violent diarrhoea with characteristic 'rice-water stools,' vomiting, thirst, muscle cramps, and sometimes circulatory collapse. Death can occur as quickly as a few hours after the onset of symptoms. The mortality rate is more than 50 percent in untreated cases, but falls to less than 1 percent with proper treatment. Treatment consists mainly of intravenous or oral replacement of fluids and salts. Packets for dilution containing the correct mixture of sodium, potassium, chloride, bicarbonate, and glucose have been made widely available by the WHO. Most patients recover in three to six days. Antibiotics such as tetracyclines, ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole can shorten the duration of the disease, but have their own long term risks in damage to the immune system. Research Cholera