St Louis is a city in Missouri, USA. The city was first settled as a fur trading post in 1764, was occupied by Spanish troops in 1771 and was under Spanish rule for thirty years. In May, 1780, the town was attacked by Indians and thirty citizens killed. In 1803 it became American, and the seat of government of the 'District of Louisiana', in 1822 it became a city. In 1849 St Louis was ravaged by fire which destroyed many of the business houses of the town. St Louis was America's first home rule city, separating from St Louis County in 1876.